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目的探讨降钙素原在细菌感染中的诊断价值,为临床诊断与治疗提供参考依据。方法选取2012年2月-2014年12月医院收治的急性感染疾病患者97例为研究对象,将45例细菌感染患者作为观察组,52例非细菌感染患者作为对照组,采集患者静脉血进行降钙素原检查,观察两组患者降钙素原检测各项指标以及炎症分布,对患者诊断敏感性和特异性进行分析;采用SPSS18.0软件对数据进行统计分析。结果观察组降钙素原检测<0.5、0.5~2.0、>2.0ng/ml的患者分别为3、26、16例,对照组患者分别为43、8、1例,两组比较差异有统计学意义(P<0.05);患者各项炎症指标对于细菌敏感性、特异性的检测显示,45例细菌感染患者中白细胞总数达到临界值的为40例,中性粒细胞比值达到临界值的为37例,PCT水平达到临界值的为26例,而52例非细菌感染患者中白细胞总数达到临界值的为23例,中性粒细胞比值达到临界值的为20例,PCT水平达到临界值的为9例,PCT的敏感性及特异性均高于中性粒细胞比值以及白细胞总数。结论降钙素原检查对于细菌感染患者具有很好的特异性及敏感性,对于细菌感染患者的诊断检查具有较高的临床意义。
Objective To investigate the diagnostic value of procalcitonin in bacterial infection and provide reference for clinical diagnosis and treatment. Methods A total of 97 patients with acute infectious diseases admitted from February 2012 to December 2014 in our hospital were enrolled in this study. Forty-five patients with bacterial infection were selected as the observation group and 52 patients with non-bacterial infection as the control group. Venous blood samples were collected for reduction Pretreatment of calcitonin, the detection of procalcitonin in both groups of patients with indicators of inflammation and the distribution of the diagnosis of the sensitivity and specificity of the analysis; using SPSS18.0 software for statistical analysis of the data. Results The observation group of procalcitonin detection of <0.5,0.5 ~ 2.0,> 2.0ng / ml of patients were 3,26,16 cases, respectively, the control group were 43,8,1 patients, the difference between the two groups were statistically significant (P <0.05). The sensitivity and specificity of each index of inflammation in patients with bacteria showed that 40 of the 45 patients with bacterial infection reached the critical value and the neutrophil ratio reached the critical value of 37 Cases, PCT levels reached the critical value of 26 cases, and 52 cases of non-bacterial infection in patients with leukocyte count reached the critical value of 23 cases, the neutrophil count reached a critical value of 20 cases, PCT levels reached the critical value of Nine cases, PCT sensitivity and specificity were higher than the neutrophil ratio and the total number of leukocytes. Conclusion The procalcitonin test has good specificity and sensitivity for patients with bacterial infection and has high clinical significance for the diagnosis of patients with bacterial infection.