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1例19岁男性传染性单核细胞增多症患者拟给予阿昔洛韦600 mg加入10%葡萄糖注射液250 ml中静脉滴注。但因用药错误将阿昔洛韦3.0 g加入10%葡萄糖注射液250 ml中静脉滴注。输注完毕后9 h,患者出现明显腰痛,尿量减少,尿蛋白(++),尿潜血(++)。随后出现24 h无尿。第3天肾功能检查:血清肌酐557μmol/L,尿素9.2 mmol/L。肾脏超声示双肾弥漫性病变。行血液净化,并给予甲泼尼龙40 mg/d静脉滴注,治疗2 d。肾功能逐渐好转,尿量增多。第15天患者肾功能及尿常规检查均无异常,痊愈出院。
A 19-year-old man with infectious mononucleosis was given intravenous infusion of acyclovir 600 mg in 250 ml of 10% glucose injection. But due to wrong medication will acyclovir 3.0 g 10% glucose injection 250 ml intravenous infusion. Nine hours after the infusion, the patient developed significant back pain, reduced urine output, urinary protein (++), and urine occult blood (++). Then there was 24 hours without urine. The third day renal function tests: serum creatinine 557μmol / L, urea 9.2mmol / L. Renal ultrasound showed diffuse renal disease. Blood purification, and given methylprednisolone 40 mg / d intravenous infusion, treatment 2 d. Kidney function gradually improved, increased urine output. On the 15th day, there was no abnormality in renal function and urine routine examination, and he was discharged.