目的 :了解褪黑素受体 (ＭＲ)体内分布有助于阐明褪黑素 (ＭＥＬ)广泛生物学作用。方法 :选用中期引产胎儿 ,取出心、肝、肺、肾、胃肠、甲状腺、胸腺、脾、外周血白细胞等组织。组织匀浆后 ,440 0 0×ｇ离心 2 5ｍｉｎ ,分离出膜蛋白。然后应用放射配体法检测 2 - [1 2 5Ｉ]褪 OBJECTIVE: To understand the in vivo distribution of melatonin receptors (MR) helps elucidate the broad biological role of melatonin (MEL). Methods: Selection of mid-term fetus fetus, remove the heart, liver, lung, kidney, gastrointestinal, thyroid, thymus, spleen, peripheral blood leukocytes and other tissues. After homogenization, the membrane proteins were isolated by centrifugation at 440 × 0 × g for 25 min. Radioligand method was then used to detect 2 - [1 2 5I] fade