口腔扁平苔藓（ＯＬＰ）是一种常见的皮肤粘膜病，其病因较为复杂，基本病理特征为Ｔ淋巴细胞带状浸润。其浸润过程分为：细胞因子产生阶段；Ｔ淋巴因子募集到位阶段；上皮组织内趋化阶段；滞留保持阶段。并且指出，各种细胞因子的产生，引起细胞表面三对粘附分子的表达，是淋巴细胞浸润的关键。所以如何阻断淋巴细胞和血管内皮细胞、上皮角肮细胞的粘附是ＯＬＰ治疗突破点。 Oral lichen planus (OLP) is a common skin and mucosal disease, the etiology is more complicated, the basic pathological features of T lymphocyte infiltration. The infiltration process is divided into: cytokine production phase; T lymphokine recruitment stage; epithelial tissue chemotaxis stage; retention and retention stage. And pointed out that the production of various cytokines, causing cell surface expression of three pairs of adhesion molecules, is the key to lymphocyte infiltration. So how to block the adhesion of lymphocytes and vascular endothelial cells, epithelial cells is the breakthrough of OLP treatment.