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早在1924年Clarkc首先从人类龋齿中分离出一种链球菌,并首次提出这种细菌是引起人类龋齿的病原菌。由于其形态的多变性,被称勾变形链球菌(Streptocous mutans),这种变形链球菌迄今不能被包括在Lamcefield分群中,是具有共同特性的包括8个血清型的一类链球菌。变形链球菌与龋齿病的发生和发展有关,这已是被大家公认的事实。这种细菌从患有龋齿病的儿童牙菌斑中分离的阳性率几乎达到100％,而没有龋齿病的儿童牙菌斑的阳性率
As early as 1924, Clarkc first isolated a streptococcus from human dental caries and for the first time suggested that the bacterium is the causative agent of human caries. Due to its morphological variability, it is said to be Streptocous mutans, which so far can not be included in the Lamcefield group, is a group of Streptococcus including 8 serotypes with common properties. Streptococcus mutans and the occurrence and development of dental caries, which has been recognized as a fact. The positive rate of this bacterium isolated from dental plaque of children with dental caries was almost 100%, while the positive rate of plaque in children without dental caries