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目的筛选评价20种中药提取物对牙龈卟啉单胞菌抑制作用。方法选择20种有较强抑菌作用及清热解毒作用的中药提取物,采用杯碟法进行体外抑菌试验,比较各中药对牙龈卟啉单胞菌的抑菌环直径和最低抑菌浓度(MIC)。结果水煎剂中黄连、乌梅、五味子、五倍子和黄芩的MIC为0.0488~1.5625mg/mL。油剂中丁香油、香薷油的MIC为0.3906~1.5625mg/mL。结论本实验选择的20种中药提取物中香薷油、黄连、乌梅、五味子、五倍子和黄芩的抑菌敏感度最高。
Objective To screen and evaluate the inhibitory effect of 20 Chinese herbal extracts on Porphyromonas gingivalis. Methods Twenty kinds of traditional Chinese medicine extracts with strong antibacterial activity and detoxification were selected and in vitro antibacterial tests were conducted by cup-plate method. The diameters of antibacterial rings and minimum inhibitory concentrations (MICs) of P. gingivalis MIC). Results The MICs of berberine, ebony, schisandra chinensis, gallnut and Scutellaria baicalensis were 0.0488 ~ 1.5625mg / mL. The oil in the clove oil, incense emu oil MIC 0.3906 ~ 1.5625mg / mL. Conclusion The antimicrobial susceptibility of the twenty traditional Chinese medicine extracts selected from the group consisting of savory oil, berberine, plum, schisandra chinensis, gallnut and Scutellaria baicalensis Georgi was the highest.