Abramov等由亚磷酸二酯和羰基化合物在醇钠的催化下合成一系列α-羟基取代烷基膦酸二酯,(RO)_2P(O)CR′R″OH。在其工作中,发现有些亚磷酸二酯不能或不易和较复杂的醛和酮加成,即使发生作用,而产物不能析出或提纯。作者现在试用不同的芳香醛,肉桂醛和环己酮,与亚磷酸二(β-氯乙基)酯作用,在少量的甲醇钠-甲醇的饱和溶液存在下,发生放热加成反应,产生九种新的固体α-羟基取代烷基膦酸二(β-氯乙基)酯。在实验过程中,产物最初多成胶状的半固体,但是经过冰冷及磨擦器壁,终於变成很好的结晶。作者鉴於α-羟基三氯乙基二甲基膦酸酯和α-羟基三氯乙基二乙基膦酸酯以 Abramov et al. Synthesized a series of α-hydroxy substituted alkylphosphonic acid diesters, (RO) _2P (O) CR’R "OH catalyzed by phosphites diesters and carbonyls in the presence of sodium alcoholates. In their work, some The phosphite diesters can not or are not readily complex with the more complex aldehydes and ketones, and the products do not precipitate or purify even when they are active. The authors now try different aromatic aldehydes, cinnamaldehyde and cyclohexanone, Chloroethyl) ester, an exothermic addition reaction takes place in the presence of a small amount of a saturated solution of sodium methoxide-methanol, yielding nine new classes of bis (β-chloroethyl) esters of α-hydroxy substituted alkylphosphonic acid During the experiment, the product initially became a multi-gelatinous semi-solid, but finally became a good crystal after passing through ice-cold and friction wall. The authors consider that α-hydroxytrichloroethyl dimethyl phosphonate and α-hydroxy trichloroethyl diethyl phosphonate