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目的 :研究结肠及直肠癌活体组织中血管内皮生长因子 (VEGF)、p53蛋白和增殖细胞核抗原 (PCNA)表达与淋巴结转移的关系。方法 :应用病理学诊断的方法检查淋巴结有无癌细胞转移。直肠癌组织标本做VEGF、p53蛋白和PCNA免疫组织化学染色。结果 :VEGF阳性表达的结肠及直肠癌患者淋巴结转移率为 65 .91 % (2 9/ 4 4 ) ,VEGF阴性的患者淋巴结转移率为 1 9.2 8% (1 6/ 83) ,差异有极显著意义 (χ2 =1 2 .0 777,P <0 .0 0 1 ) ;而p53及PCNA阳性表达的患者淋巴结转移和阴性表达患者的淋巴结转移之间差异无显著意义。结论 :结肠及直肠癌组织中VEGF的表达可为患者的淋巴结转移情况的判断及预后提供重要的参考依据
Objective: To study the relationship between the expression of vascular endothelial growth factor (VEGF), p53 protein and proliferating cell nuclear antigen (PCNA) and the lymph node metastasis in colorectal and rectal cancer tissues. Methods: The pathological diagnosis of lymph nodes with or without cancer cell metastasis. The specimens of rectal cancer were immunohistochemically stained for VEGF, p53 and PCNA. Results: The rate of lymph node metastasis was 65.91% (2 9/4 4) in VEGF-positive colorectal cancer patients and 1 9.28% (16/83) in VEGF-negative patients, the difference was significant (Χ2 = 12.0777, P <0.001). There was no significant difference between lymph node metastasis and negative lymph node metastasis in patients with positive p53 and PCNA expression. Conclusion: The expression of VEGF in colorectal and rectal cancer tissues may provide an important reference for the judgment and prognosis of patients with lymph node metastasis