目的:比较两种不同提取方法对益心舒胶囊中人参皂苷Rg1和Re含量及总量的影响。方法:对照组按《中国药典》2010版提取方法;实验组采用三氯甲烷回流,药渣加入水饱和正丁醇液,密塞,放置过夜,超声处理并过滤,续滤液采用正丁醇饱和氨试液提取3次,正丁醇层液置于蒸发皿加热蒸干,残渣加甲醇溶解并转移至容量瓶。其中人参皂苷Rg1和Re采用《中国药典》2010版含量测定方法测定。结果:经检测,对照组人参皂苷Rg1含量为0.71mg/g,Re含量为4.29mg/g,Rg1和Re总含量为5.00mg/g;观察组人参皂苷Rg1含量为0.34mg/g,Re含量为2.33mg/g,Rg1和Re总总量为2.67mg/g。结论:研究表明,与对照组比较,实验组提取过程简单,周期较短,但人参皂苷Rg1、Re含量及总量均较低,改进提取方法、缩短周期、简化过程、提高提取含量测定结果将是下一步实验研究的方向。 Objective: To compare the effects of two different extraction methods on the content and the total amount of ginsenosides Rg1 and Re in Yixinshu capsule. Methods: The control group according to the “Chinese Pharmacopoeia” 2010 version of the extraction method; experimental group using chloroform reflux, dregs added water saturated n-butanol solution, Mesa, overnight, sonicated and filtered, the filtrate was saturated with n-butanol Ammonia test solution was extracted three times, n-butanol layer was placed in the evaporating dish heating evaporated, the residue dissolved in methanol and transferred to a volumetric flask. Which ginsenosides Rg1 and Re using “Chinese Pharmacopoeia” 2010 version content determination method. Results: The content of ginsenoside Rg1 in the control group was 0.71mg / g, the content of Re was 4.29mg / g, the total content of Rg1 and Re was 5.00mg / g. The content of ginsenoside Rg1 in observation group was 0.34mg / g, the content of Re Was 2.33 mg / g, and the total amount of Rg1 and Re was 2.67 mg / g. Conclusion: Compared with the control group, the experimental group has a simple extraction process and short cycle, but the content and total amount of ginsenoside Rg1, Re are lower, the extraction method is improved, the cycle is shortened, the process is simplified, and the determination result of extraction content is improved Is the direction of the next experimental study.