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目的 评价胰岛素泵连续皮下输注 (CSII)与静脉连续输注泵 (CVII)治疗糖尿病酮症酸中毒的疗效差异。方法 30例糖尿病酮症酸中毒患者分 2组 :(1)胰岛素泵连续皮下输注治疗 (CSII)组 15例 ;(2 )静脉连续输注泵治疗 (CVII)组 15例。结果 两组治疗后血糖均能明显下降 ,CSII组优于CVII组 ,差异有显著性 (P <0 0 1) ;CSII组平均胰岛素用量为 (0 6 7± 0 14 )U/ (kg·d)明显少于CVII组 (0 82±0 16 )U/ (kg·d) (P <0 0 5 ) ;CSII组尿酮体转阴时间为 (17 5± 7 4 )h明显短于CVII组 (4 1 2± 12 1)h(P <0 0 1) ;CSII组低血糖发生率为 (0 5 2± 0 2 2 )次 /人 ,显著低于CVII组的 (0 75± 0 2 6 )次 /人 ,(P <0 0 5 )。结论 CSII模拟胰岛素的生理分泌模式 ,能更快、更有效地纠正代谢紊乱 ,控制高血糖 ,明显改善生活质量。
Objective To evaluate the efficacy of continuous subcutaneous infusion of insulin pump (CSII) and intravenous continuous infusion pump (CVII) in the treatment of diabetic ketoacidosis. Methods Thirty patients with diabetic ketoacidosis were divided into two groups: (1) 15 patients underwent continuous subcutaneous infusion of insulin pump (CSII); and (2) 15 patients underwent continuous intravenous infusion pump (CVII). Results The blood glucose of the two groups were significantly decreased after treatment, the CSII group was superior to the CVII group, the difference was significant (P <0.01); the average insulin dosage of CSII group was (0 6 7 ± 0 14) U / (kg · d ) Was significantly lower than that of CVII group (0 82 ± 0 16 U / (kg · d)) (P <0 05); CSII group was significantly shorter than that of CVII group (17 5 ± 7 4 h) 1 2 ± 12 1 h (P 0 01). The incidence of hypoglycemia in CSII group was (0 52 ± 0 2 2) times per person, which was significantly lower than that in CVII group (0 75 ± 0 2 6) times / Person, (P <0 0 5). Conclusion CSII simulates the physiological secretion pattern of insulin, which can correct metabolic disorders more quickly and more effectively, control hyperglycemia and significantly improve the quality of life.