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目的观察口服食盐胶囊和静脉补钠两种方法对充血性心力衰竭(congestive heart failure,CHF)患者合并低钠血症的疗效。方法对43例CHF合并低钠血症的住院患者血钠进行分析,了解血钠与纽约心脏协会(NYHA)心功能分级的关系,并根据补钠方法随机分为口服食盐胶囊组(21例)和静脉补钠组(22例),检测每组治疗前后血钠的水平及NYHA心功能分级。结果 NYHA心功能不同分级患者血钠水平差异有统计学意义,NYHAⅢ级血钠(125.12±2.88)mmol/L,NYHAⅣ级血钠(121.87±3.49)mmol/L(P<0.01),连续观察治疗3天,静脉补钠组患者血钠水平和心功能改善率明显高于口服食盐胶囊组(P<0.05或<0.01)。结论 CHF患者低钠程度重者心力衰竭亦严重,且静脉补钠是纠正CHF患者低钠血症、改善心功能较好的一种方法 。
Objective To observe the efficacy of oral salt capsule and intravenous sodium regimen in patients with congestive heart failure (CHF) complicated with hyponatremia. Methods Thirty-three inpatients with CHF and hyponatremia were enrolled in this study. The relationship between serum sodium and cardiac function in New York Heart Association (NYHA) was analyzed. The patients were randomly divided into two groups according to sodium supplementation: And sodium supplementation group (n = 22). Serum sodium level and NYHA functional class were tested before and after treatment. Results There was significant difference in the level of serum sodium among NYHA class patients with different grades of heart function. NYHA class Ⅲ serum sodium (125.12 ± 2.88) mmol / L and NYHA Ⅳ class serum sodium (121.87 ± 3.49) mmol / L (P <0.01) On the 3rd day, the serum sodium level and the improvement rate of cardiac function in the sodium supplementation group were significantly higher than those in the oral salt group (P <0.05 or <0.01). Conclusion Severe hyponatremia in CHF patients with severe heart failure is also serious, and intravenous sodium supplementation is a method to correct hyponatremia and improve cardiac function in CHF patients.