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目的探讨血清超敏C反应蛋白(hs-CRP)在冠心病中的表达特性。方法随机选取56例冠心病患者,包括稳定型心绞痛19例,不稳定型心绞痛19例,急性心绞硬死18例,并以48例健康人作为对照组。在全自动生化分析仪上应用乳胶增强免疫透射比浊法测定血清中hs-CRP的浓度,并分析治疗前后hs-CRP水平的差异。结果冠心病患者中hs-CRP浓度与对照组相比明显增高,差异具有统计学意义(P<0.01)。冠心病各组的hs-CRP水平在治疗前后比较有统计学意义(P<0.01)。结论冠心病患者血清hs-CRP水平的增高与冠心病的发生、发展显著相关,检测hs-CRP对冠心病的辅助诊断、疗效观察及预后判断具有重要价值。
Objective To investigate the expression of serum hs-CRP in coronary heart disease. Methods Fifty-six patients with coronary heart disease were randomly selected, including 19 patients with stable angina pectoris, 19 patients with unstable angina pectoris, and 18 patients with acute myocardial infarction. 48 healthy subjects were included as control group. The concentration of hs-CRP in serum was detected by latex enhanced immunoturbidimetry on the automatic biochemical analyzer, and the difference of hs-CRP level before and after treatment was analyzed. Results The concentration of hs-CRP in patients with coronary heart disease was significantly higher than that in the control group (P <0.01). The levels of hs-CRP in each group of coronary heart disease were statistically significant before and after treatment (P <0.01). Conclusion The increase of serum hs-CRP in patients with coronary heart disease is significantly associated with the occurrence and development of coronary heart disease. Detection of hs-CRP is of great value in the diagnosis, prognosis and curative effect of coronary heart disease.