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目的：探讨双能源胃肠外营养（ＰＮ）对肝切除后肝脏脂肪变性的影响。方法：将大鼠随机分为３组：Ⅰ组不手术，自由摄食；Ⅱ组６５％肝切除后用单能源ＰＮ治疗；Ⅲ组术后用双能源ＰＮ治疗。分别于实验第三、六天观察肝脏脂肪变性的改变及再生反应。结果：Ⅲ组肝细胞脂肪变性和水样变性明显减轻，肝重／体重、肝脏再生率均高于Ⅱ期（Ｐ＜０．０１和Ｐ＜０．０５），Ⅱ、Ⅲ组肝细胞有丝分裂率和ＤＮＡ合成率无明显差异。结论：肝切除后运用双能源ＰＮ治疗，具有促进肝脏再生，减轻肝脏脂肪变性和水样变性的作用，可能与血中胰岛素／胰高糖素比值下降有关。
Objective: To investigate the effect of dual energy parenteral nutrition (PN) on hepatic steatosis after hepatectomy. Methods: The rats were randomly divided into three groups: group Ⅰ without operation, free feeding; group Ⅱ 65% hepatectomy with single energy PN treatment; Ⅲ group after treatment with dual energy PN. The changes of hepatic steatosis and the regenerative responses were observed on the third and sixth days respectively. Results: The hepatic steatosis and watery degeneration in group Ⅲ were significantly reduced, and the liver weight / body weight and liver regeneration rate were higher than those in stage Ⅱ (P <0.01 and P <0.05). The mitotic rate of hepatocytes in group Ⅱ and Ⅲ And DNA synthesis rate no significant difference. Conclusion: The use of dual-energy PN after hepatectomy has the effect of promoting liver regeneration, reducing hepatic steatosis and water degeneration, which may be related to the decrease of blood insulin / glucagon ratio.