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血小板生成素(TPO)是巨核细胞增殖、成熟和血小板产生的主要调节因子,并且在成熟血小板生成中,TPO的作用强于目前已知的几种相关造血因子。TPO模拟肽(TPOmimeticpeptide,TMP)或TPO非肽类模拟物(TPOnonpeptidemimics)是与TPO具有相似功能但不具有同源结构的小分子物质,能与TPO受体结合,产生类似TPO的生物学作用,且不具有免疫原性,因而越来越受到青睐。本文对TPO及其模拟物的研究进展进行综述。
Thrombopoietin (TPO) is a major regulator of megakaryocyte proliferation, maturation and platelet production, and in mature platelet production, TPO is more potent than several known hematopoietic factors presently known. TPO mimetic peptide (TPO mimetic peptide, TMP) or TPO non-peptide mimics (TPO non-peptide mimics) is a small molecule with similar function TPO but does not have the same structure, can bind with the TPO receptor, resulting in a biological effect similar to TPO, And is not immunogenic, and therefore more and more favored. This article reviews the progress of TPO and its mimics.