遗传性压力敏感性周围神经病(HNPP)是一种常染色体显性遗传的周围神经病。HNPP的分子基础是染色体17p11.2区的一个1.5Mb片段缺失。临床特点为反复发作的在易卡压部位神经受压后,受累神经所支配区域出现运动感觉障碍。本病早期准确诊断后采取预防措施可减少发作。本文就HNPP的病因、临床特点及诊断等作一综述。 Hereditary stress-sensitive peripheral neuropathy (HNPP) is an autosomal dominant inherited peripheral neuropathy. The molecular basis of HNPP is the deletion of a 1.5 Mb fragment of chromosome 17p11.2. Clinical features of recurrent episodes of nerve compression in the easy parts, the affected area dominated by motor sensory dysfunction. Precaution early diagnosis of the disease to take preventive measures to reduce the attack. This article reviews the etiology, clinical features and diagnosis of HNPP.