1例25岁女性因便秘自行服用苁蓉通便口服液20 ml、1次/d。间断服药3个月后患者逐渐出现尿黄、皮肤及巩膜黄染，伴恶心、呕吐、食欲下降等症状。4个月后实验室检查示：丙氨酸转氨酶（ALT）1 359 U/L，天冬氨酸转氨酶（AST）859 U/L，碱性磷酸酶（ALP）160 U/L，总胆红素（TBil）131.5 μmol/L，直接胆红素（DBil）99.3 μmol/L。考虑为苁蓉通便口服液所致肝损伤，遂停用该药，给予异甘草酸镁注射液200 mg溶于5%葡萄糖注射液250 ml静脉滴注、1次/d，多烯磷脂酰胆碱注射液20 ml溶于5%葡萄糖注射液250 ml静脉滴注、1次/d。治疗后，患者症状逐渐好转。2周后，患者尿色基本正常，消化道症状消失，复查肝功能：ALT 137 U/L，AST 87 U/L，ALP 126 U/L，TBil 34.9 μmol/L。2个月后随访，患者的肝功能恢复正常。患者的肝损伤很可能与苁蓉通便口服液中的何首乌成分有关。“,”A 25-year-old female patient took n Congrong Tongbian oral liquid 20 ml once daily by herself for constipation. After 3 months of intermittent medication, the patient gradually developed dark urine and yellowish skin and sclera, accompanied by nausea, vomiting, and decreased appetite; 4 months later, laboratory tests showed alanine aminotransferase (ALT) 1 359 U/L, aspartate aminotransferase (AST) 859 U/L, alkaline phosphatase (ALP) 160 U/L, total bilirubin (TBil) 131.5 μmol/L, and direct bilirubin (DBil) 99.3 μmol/L. Liver injury caused by n Congrong Tongbian oral liquid was considered, then the drug was discontinued, and IV infusions of magnesium isoglycyrrhizinate injection 200 mg dissolved in 5% glucose injection 250 ml once daily and polyene phosphatidylcholine injection 20 ml dissolved in 5% glucose injection 250 ml once daily were given. After the above treatments, the patient′s symptoms were gradually improved. Two weeks later, the patient′s urine color was basically normal, gastrointestinal symptoms disappeared, and liver function showed ALT 137 U/L, AST 87 U/L, ALP 126 U/L, and TBil 34.9 μmol/L. At a 2-month follow-up, the patient′s liver function returned to normal. The patient′s liver injury was most likely related to the n Polygonum multiflorum in n Congrong Tongbian oral liquid.n