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高效抗反转录病毒治疗(HAART)的应用,极大地降低了艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)并发症的发病率和病死率。然而,部分晚期AIDS病人的病毒抑制与免疫重建并不同步,发生免疫重建炎症综合征(IRIS)或免疫重建失败(INR),极大地影响了临床预后。文章针对HAART后免疫重建的特点、影响因素及治疗手段相关的研究进展进行综述。
The use of highly effective antiretroviral therapy (HAART) has greatly reduced the morbidity and mortality of complications associated with HIV / AIDS patients (referred to as HIV / AIDS patients). However, some patients with advanced AIDS virus inhibition and immune reconstruction are not synchronized, the occurrence of immune reconstruction inflammatory syndrome (IRIS) or immune reconstruction failure (INR), has greatly affected the clinical prognosis. The article reviews the characteristics of immune reconstruction after HAART, the influencing factors and the research progress of treatment.