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动脉血乳酸盐监测可用以区别代谢性酸中毒性质,对估价病人预后,有一定的实用价值。现将乳酸产生的生化过程、影响其生成和代谢的因素、乳酸酸中毒的发生机制及对其监测的评价等综述如下。一、氧在代谢中的作用在线粒体表面必须维持适当氧张力,以使线粒体能进行氧化磷酸化作用。氧化磷酸化能由食物氧化合成三磷酸腺甙(ATP)而获得能量,因此这是一耗氧过程。ATP 是化学能贮存形式,当 ATP 转化为二磷酸腺甙(ADP)时,提供给细胞以自由能,这对需能过程的完成很必要。线粒体氧化磷酸
Arterial lactate monitoring can be used to distinguish metabolic acidosis, the prognosis of the valuation of patients, have some practical value. Now the biochemical process of lactic acid, the factors that affect its formation and metabolism, the mechanism of lactic acidosis and evaluation of its monitoring are summarized as follows. First, the role of oxygen in metabolism Mitochondrial surface must maintain proper oxygen tension, so that mitochondria can oxidative phosphorylation. Oxidative phosphorylation energy from the oxidation of food synthesis of adenosine triphosphate (ATP), so this is an oxygen consumption process. ATP is a form of chemical energy storage. When ATP is converted to adenosine diphosphate (ADP), the ATP is provided to the cells for free energy, which is necessary for the completion of the energy requirement process. Mitochondrial oxidation of phosphoric acid