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目的观察2型糖尿病及合并大血管病变患者血浆CRP、PAI-1、t-PA、 Fbg水平的变化,探讨这些指标的变化在2型糖尿病动脉粥样硬化中的意义和特性。方法采用免疫比浊法,酶联免疫吸驸双抗体夹心法和血凝分析仪,分别检测单纯糖尿病组60例,合并大血管病变组74例和正常对照组46例血浆CRP、PAI -t、t-PA和Fbg浓度。结果2型糖尿病组及2型糖尿病合并大血管病变组的 CRP、PAl-1、Fbg水平均高于正常对照组(P<0．05,P<0．01),2型糖尿病合并大血管病变组的CRP、PAt-1、Fbg水平又明显高于单纯2型糖尿病组(P<0．05,P< 0．01),t-PA水平在各组问差异无显著性。结论具有致动脉粥样硬化作用的炎症指标——CRP和反映纤溶活性降低的PAl-1以及血栓前体物质——Fbg等水平的升高,均与2型糖尿病动脉硬化、斑块形成和血栓形成有关,降低CRP、PAI- 1水平或活性可能延缓动脉粥样硬化的发展,减少糖尿病心、脑血管疾病的发生。
Objective To observe the changes of plasma CRP, PAI-1, t-PA and Fbg in patients with type 2 diabetes mellitus and macroangiopathy and to explore the significance and characteristics of the changes of these indexes in atherosclerosis type 2 diabetes mellitus. Methods Immunoturbidimetry, enzyme-linked immunosorbent assay (ELISA) and double antibody sandwich method were used to detect the plasma levels of CRP, PAI-t in 60 patients with simple diabetes mellitus, 74 patients with macrovascular complications and 46 healthy controls. t-PA and Fbg concentrations. Results The levels of CRP, PAI-1 and Fbg in type 2 diabetes mellitus and type 2 diabetic patients with macroangiopathy were significantly higher than those in normal controls (P <0.05, P <0.01), type 2 diabetes mellitus with macrovascular complications The levels of CRP, PAt-1 and Fbg were significantly higher in patients with type 2 diabetes mellitus (P <0.05, P <0.01). There was no significant difference in the levels of t-PA between the groups. Conclusions The elevated levels of CRP and PAl-1, which reflect the reduction of fibrinolytic activity and fibrinogen, which is the target of atherosclerosis, are associated with atherosclerosis and plaque formation in type 2 diabetes mellitus Thrombosis, reduce CRP, PAI-1 levels or activity may delay the development of atherosclerosis and reduce the occurrence of diabetic heart and cerebrovascular diseases.