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支气管哮喘症状是气道炎症的表现,后者主要由嗜酸粒细胞、肥大细胞和中性粒细胞等炎症细胞对支气管壁的浸润所致。上述炎症细胞激活后释放包括过氧化氢(H_2O_2)在内的介质和细胞因子。H_2O_2损伤气道粘膜上皮,引起气道反应性增高和加重炎症反应过程,并使细胞膜脂类过氧化产生硫巴比土酸反应产物(TBARs)。本研究主要是观察哮喘患者呼出气中是否含有比正常人更高的H_2O_2和TBARs。
Bronchial asthma symptoms are manifestations of airway inflammation, which is caused mainly by infiltration of the bronchial wall by inflammatory cells such as eosinophils, mast cells and neutrophils. Upon activation of the above inflammatory cells, media and cytokines including hydrogen peroxide (H 2 O 2) are released. H 2 O 2 can injure airway mucosa epithelium, causing airway hyperresponsiveness and exacerbating the inflammatory reaction process, and lipid peroxidation of cell membrane produces thiobarbituric acid reaction products (TBARs). The purpose of this study was to observe if the exhaled breath of asthmatic patients contains higher levels of H 2 O 2 and TBARs than normal subjects.