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双(β-氯乙基)胺系一类对肿瘤生长确具显著抑制作用的化合物,它的氨基酸衍生物已获得了广泛的注意。例如对位-双(β-氯乙基)氨基苯丙氨酸(溶肉瘤素)(Ia)及它的多肽化合物的抗肿瘤作用不仅在实驗治疗上得到了証实并已应用于临床。我们曾研究过它的合成法。本文是报导溶肉瘤素的合成改良法及其异构体的制备。
Bis (β-chloroethyl) amine is a class of compounds that have a significant inhibitory effect on tumor growth. Its amino acid derivatives have received a great deal of attention. For example, the anti-tumor effect of para-bis (beta-chloroethyl) aminophenylalanine (Ia) and its polypeptide compounds has not only been demonstrated experimentally but has been clinically proven. We have studied its synthesis method. This article is a report of the synthesis of soluble sarcoma improved method and the preparation of its isomers.