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治疗冠心病的药物,若能改善或阻断损害心肌细咆的主要环节,才会取得良好的治疗效果。近年来发现冠心病患者心绞痛发作时,出现心电图异常,同时冠状窦流出伪血液中可检出一种血小板活化因子(plateletactiviting factor,PAF)。也发现心肌梗塞患者的血小板,在体外试验对PAF 致聚作用的敏感性增高,对前列腺素(PGI_2)抑制血小板聚集的敏感性下降。实验还证明,在心肌缺血过程中体内多种细胞如血管内皮细胞、血小板、白细胞等会释放出过量
The treatment of coronary heart disease, if it can improve or block the main part of the damage of myocardial infarction, will achieve good therapeutic effect. In recent years, an abnormal electrocardiogram (ECG) has been observed during the onset of angina in patients with coronary heart disease. At the same time, a platelet activiting factor (PAF) can be detected in the coronary sinus outflow of pseudo-blood. It has also been found that platelets from patients with myocardial infarction have increased sensitivity to PAF polypolymerization in vitro and decreased sensitivity to prostaglandin (PGI2) inhibition of platelet aggregation. Experiments also showed that in the course of myocardial ischemia, many cells in the body, such as vascular endothelial cells, platelets, and white blood cells, will release excessive amounts of