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目的:研究新疆维吾尔族(维族)和汉族多囊卵巢综合症(PCOS)患者的临床,内分泌特点及一级亲属的临床表型及其他们之间的差异。方法:将201例PCOS患者分为维,汉两组,采用问卷调查及临床相关检查方法,对患者的临床特征,各项临床检验指标进行分析,同时对父母亲相关情况进行调查分析。结果:(1)汉维两组患者的年龄、初潮年龄、经期天数、子宫内膜厚度、体质指数、腰臀比、卵巢体积以及卵泡数之间差异均无统计学意义(P>0.05),而月经周期、痤疮、多毛症状的发生率比较差异有统计学意义(P<0.05)。(2)维,汉两组患者的女性激素六项及糖脂代谢指标比较,维族患者雄激素及甘油三酯水平较汉族患者高,差异有统计学意义(P<0.05),而汉族患者总胆固醇水平较维族患者高,差异有统计学意义(P<0.05)。结论:汉,维两组PCOS患者在内分泌及脂代谢方面存在一定差异。
Objective: To investigate the clinical and endocrine characteristics of Uygur and Han women with polycystic ovary syndrome (PCOS) in Xinjiang and their clinical phenotypes and their differences among the first degree relatives. Methods: 201 cases of PCOS patients were divided into two groups: Victoria and Han. The clinical characteristics and clinical indicators of the patients were analyzed by questionnaire and clinically relevant tests. Meanwhile, the related situation of the parents was investigated and analyzed. Results: (1) There was no significant difference in the age, menarche age, days of menstruation, endometrial thickness, body mass index, waist-hip ratio, ovarian volume and follicle count between the two groups (P> 0.05) The menstrual cycle, acne, hirsutism incidence was significantly different (P <0.05). (2) Compared with six indexes of female hormones and glycometabolism and lipid metabolism in Uygur and Han patients, Uygur patients had higher levels of androgen and triglyceride than Han patients (P <0.05), while Han patients Cholesterol level than Uighur patients, the difference was statistically significant (P <0.05). Conclusion: There are some differences in the endocrine and lipid metabolism between Han and Wei patients with PCOS.