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目的:观察喜炎平治疗小儿细菌性肺炎的疗效及其对血清细胞因子IL-1β、IL-6、IL-8、TNF-α的影响,探讨其免疫作用机制。方法:将94例小儿细菌性肺炎患儿随机分为对照组和治疗组各47例,均给予头孢噻肟50~100 mg/(kg·d)加入5%GS100~250 mL中静脉滴注,3次/日;治疗组在此基础上加用喜炎平注射液5~10 mg/(kg·d)加入5%GS或生理盐水100~150 mL中缓慢静脉滴注;两组均以5 d为1疗程,治疗2~3疗程之后停3 d再治疗3 d,并酌情给予止咳、祛痰等对症治疗,观察疗效;检测两组患儿治疗前后血清IL-1β、IL-6、IL-8、TNF-α水平,进行对比分析。结果:与治疗前比较,治疗后两组患儿血清IL-1β、IL-6、IL-8、TNF-α水平均降低(P<0.05),治疗组比对照组降低更明显(P<0.05);治疗组痊愈率、总有效率分别为68.09%、93.62%,对照组分别为48.94%、80.85%,两组比较差异有统计学意义(P<0.05)。结论:喜炎平注射液治疗小儿细菌性肺炎的机制可能与改变细胞因子水平、调节免疫功能有关。
Objective: To observe the therapeutic effect of Xiyanping on bacterial pneumonia in children and its effect on serum cytokines IL-1β, IL-6, IL-8 and TNF-α, and to explore its mechanism of immune function. Methods: Ninety-four children with bacterial pneumonia were randomly divided into control group and treatment group, 47 cases in each group were given cefotaxime 50-100 mg / (kg · d) plus 5% GS 100 ~ 250 mL intravenous infusion, 3 times / day. On the basis of this, the treatment group was treated with slow-drip infusion of Xiyanping Injection 5 ~ 10 mg / (kg · d) by adding 5% GS or saline 100 ~ 150 mL; d for a course of treatment, 2 to 3 courses of treatment after stopping for 3 days and then for 3 days, and give cough, expectorant and other symptomatic treatment, as appropriate, to observe the effect; before and after treatment in both groups detected serum IL-1β, IL-6, IL -8, TNF-α levels, comparative analysis. Results: Compared with those before treatment, the levels of IL-1β, IL-6, IL-8 and TNF-α in the two groups were significantly decreased (P <0.05) ). The cure rate and total effective rate of the treatment group were 68.09% and 93.62% respectively, while those of the control group were 48.94% and 80.85% respectively. There was significant difference between the two groups (P <0.05). Conclusion: The mechanism of Xiyanping Injection in treating children with bacterial pneumonia may be related to changing the level of cytokines and regulating immune function.