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原癌基因EVI1位于人染色体3q26,编码一种DNA结合蛋白,研究表明EVI1基因重排与急性髓细胞白血病(AML)的发病有关。该基因可转录出两种mRNA产物即EVI1和EVI1-MDS1,本文旨在研究究竟哪种基因产物与AML发病有关。
Proto-oncogene EVI1 is located on chromosome 3q26 and encodes a DNA-binding protein. Studies have shown that EVI1 gene rearrangement is associated with the pathogenesis of acute myeloid leukemia (AML). The gene transcribes two mRNA products, EVI1 and EVI1-MDS1, and this article aims to investigate which gene products are involved in the pathogenesis of AML.