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目的分析儿童大肠埃希菌血流感染的临床特点及其对常用抗菌药物的药敏试验结果,为防控相关感染提供依据。方法回顾性收集某医院2013年1月-2015年10月确诊为大肠埃希菌感染的82例患儿临床资料,分析阳性菌株的血清分型与药物敏感性试验结果。结果发生大肠埃希菌血流感染的患儿以年龄在30 d内最多,占54.9%;有53.6%的患儿来自新生儿科,20.7%患儿患有血液肿瘤病;临床分离的大肠埃希菌的血清型以O142K86、O126K71、O44K74、O127K63、O55K59居前5位,其中以O142K86型最为多见,占24.4%。药敏试验显示,临床分离株对氨苄西林和头孢唑林的耐药率最高,分别为76.8%和70.7%;头孢亚胺培南和和哌拉西林他唑巴坦最为敏感,敏感染率均达到了97.6%。结论该医院大肠埃希菌血流感染发病以新生儿及存在血液病等基础病患儿发病率高,易侵犯中枢神经系统而诱发化脓性脑膜炎。
Objective To analyze the clinical characteristics of Escherichia coli bloodstream infection in children and its susceptibility to common antibacterial drugs test results to provide the basis for prevention and control of related infections. Methods The clinical data of 82 children diagnosed as Escherichia coli from January 2013 to October 2015 in a hospital were retrospectively collected. The serotyping and drug sensitivity test results of positive strains were analyzed. Results The incidence of Escherichia coli bloodstream infection in children with age at 30 d up to 54.9%; 53.6% of children from the neonatology, 20.7% of children with hematological neoplasms; clinical isolates of Escherichia coli The serotypes of the bacteria were O142K86, O126K71, O44K74, O127K63 and O55K59, among which the top five were O142K86 type, accounting for 24.4%. Susceptibility tests showed that the clinical isolates showed the highest rates of resistance to ampicillin and cefazolin, which were 76.8% and 70.7%, respectively; cefoperazam and piperacillin and tazobactam were the most sensitive ones Reached 97.6%. Conclusions The incidence of Escherichia coli bloodstream infection in this hospital is high in infants and newborns with underlying diseases such as blood diseases. It is easy to invade the central nervous system and induce purulent meningitis.