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四环素产品(盐酸四环素,四环素碱)中存在的杂质有脱水四环素(ATC),脱水差向四环素(EATC),差向四环素(ETC)和杂质金霉素(CTC)等。这些异构杂质的存在不仅增加了四环素的毒性,而且影响其疗效,临床上病人口服四环素后出现恶
Tetracycline products (tetracycline hydrochloride, tetracycline base) of the impurities are dehydrated tetracycline (ATC), dehydrated to tetracycline (EATC), epicyclic tetracycline (ETC) and impurities chlortetracycline (CTC) and so on. The presence of these heterogeneous impurities not only increased the toxicity of tetracycline, but also affect its efficacy, clinically patients after oral administration of tetracycline evil