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目的 了解急性一氧化碳中毒 (acutecarbonmonoxidepoisoningACMP)者血浆内皮素 (endothelinsET)与血清肿瘤坏死因子 (tumornecrosisfactorTNF)、一氧化氮 (nitrogenmonoxideNO)的变化及维拉帕米(verapamil,Ver)对它们的影响。方法 用放射免疫法分别测定ACMP时和给予维拉帕米 (verapamil,Ver)后大鼠血浆ET、血清TNF的浓度以及用改良镀铜镉还原法测定ACMP时和Ver治疗后NO的浓度。结果 大鼠ACMP时 ,血浆ET、血清TNF、NO均升高 (P <0 .0 1) ;Ver治疗可抑制血浆ET、血清TNF、NO的升高(P <0 .0 1)。结论 Ver对ACMP患者具有保护作用 ,这一结果为ACMP的早期治疗提供了一种新的启示。
Objective To investigate the changes of plasma endothelin (ET) and serum tumor necrosis factor (TNF), nitrogen monoxide (NO) in patients with acute carbon monoxide poisoning (ACMP) and the effects of verapamil (Ver) on them. Methods The concentrations of plasma ET and serum TNF in ACMP and verapamil (Ver) rats were determined by radioimmunoassay, and the concentration of NO after ACMP and Ver treated with modified copper-cadmium reduction assay. Results Plasma ET and serum TNF and NO were increased in rats with ACMP (P <0.01). The treatment with Ver was inhibited the increase of plasma ET, serum TNF and NO (P <0.01). Conclusion Ver has a protective effect on ACMP patients, and this result provides a new inspiration for the early treatment of ACMP.