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目的观察盐酸氟桂嗪治疗糖尿病神经病变(DN)的疗效及安全性。方法80例DN患者随机分为治疗组40例和对照组40例,对照组单用常规治疗,即维生素B1、维生素B12;盐酸氟桂嗪组在常规治疗的基础上,加用盐酸氟桂嗪,4周为1个疗程。两组糖尿病患者,于治疗前后测定血糖、糖化血红蛋白(HbA lc)、血常规、血生化、肝功能、肾功能及血流动力学检查,同时测定运动、感觉神经传导速度,膀胱残余尿量,下肢血管超声,记录两组病人出现的副作用。治疗后由固定医生完成症状改善情况评估。结果盐酸氟桂嗪能明显改善糖尿病神经病变的临床疗效及电生理指标、下肢血流,效果优于对照组。结论盐酸氟桂嗪可纠正DN多项病理异常,明显提高DN治疗效果。
Objective To observe the efficacy and safety of flunarizine hydrochloride in the treatment of diabetic neuropathy (DN). Methods Eighty patients with DN were randomly divided into treatment group (n = 40) and control group (n = 40). The control group was treated with routine treatment, ie, vitamin B1 and vitamin B12. Fludizine hydrochloride group was treated with flunarizine , 4 weeks for a course of treatment. Blood glucose, HbAlc, blood routine, blood biochemistry, liver function, renal function and hemodynamics were measured before and after treatment in both groups. The motor, sensory nerve conduction velocity, residual bladder volume, Lower extremity vascular ultrasound, recording the side effects of two groups of patients. After treatment, the symptom improvement was assessed by the fixed physician. Flunarizine hydrochloride can significantly improve the clinical efficacy of diabetic neuropathy and electrophysiological indicators, lower limb blood flow, the effect is better than the control group. Conclusion Flunarizine can correct a number of DN pathological changes, significantly improve the efficacy of DN treatment.