漏芦蜕皮甾酮(RUE)是从祁州漏芦根中提取的一种植源性蜕皮激素。本文以2％高脂血清培养家兔主动脉平滑肌细胞,形成细胞损伤;采用TBA萤光法,放射自显影和电镜,观察RUE与维生素E对受损细胞的影响。结果发现二种药物作用相似,均使细胞增生,细胞内过氧化脂含量降低,胞浆脂滴缩小、减少,未发现细胞死亡。由此认为RUE可能因具有抗脂质过氧化作用,保护了平滑肌细胞结构完整,从而显示出抗动脉粥样硬化的作用。 Leucodextrins (RUE) is a plant-derived ecdysone extracted from the reed rhizome of Qizhou. In this study, aortic vascular smooth muscle cells were cultured with 2% high-fat serum to induce cell damage. The effects of RUE and vitamin E on damaged cells were observed by TBA fluorescence, autoradiography and electron microscopy. The results showed that the two drugs have similar effects, all of which make the cells hyperplasia, the intracellular lipid peroxidation reduced, the lipid droplets of the cytoplasm reduced and decreased, and no cell death was found. This suggests that RUE may have anti-atherosclerotic effects by protecting the smooth muscle cells from structural integrity due to their anti-lipid peroxidation effects.