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目的采用同步放化疗对局部晚期食管癌患者进行治疗,观察、分析其临床疗效。方法选取2010年10月至2012年10月期间入住我院的60例局部晚期食管癌患者来研究,随机分为对照组和研究组,对照组采用6mV-X射线放射治疗这一单纯放疗,研究组在单纯放疗的基础上选用PF方法放疗,采用氟尿嘧啶和顺铂滴注,观察比较两组的近期疗效、远期疗效以及不良反应的出现情况。结果研究组近期总体有效率高于对照组,第1、3、5年生存率等远期疗效也好于对照组,并且两组具有显著的差异。研究组不良反应发生率高于对照组,但是两组之间无明显差异。结论相对于单一放疗,同步放化疗能提高患者的近期、远期疗效,延长患者生命,但是其不良反应较多,临床上需综合合理使用。
Objective To treat patients with locally advanced esophageal cancer by concurrent chemoradiotherapy and observe and analyze its clinical efficacy. Methods Sixty patients with locally advanced esophageal cancer admitted to our hospital from October 2010 to October 2012 were enrolled and randomly divided into control group and study group. The control group received 6mV-X-ray radiotherapy for this study. Group on the basis of radiotherapy alone on the choice of PF radiotherapy, the use of fluorouracil and cisplatin infusion observed and compared the two groups of short-term efficacy, long-term efficacy and adverse reactions. Results The overall effective rate of the study group was higher than that of the control group. The long-term efficacy of the first, third and fifth year survival rates was also better than that of the control group, and the two groups had significant differences. The incidence of adverse reactions in the study group was higher than that in the control group, but there was no significant difference between the two groups. Conclusions Compared with single radiotherapy, concurrent chemoradiotherapy can improve the short-term and long-term effects of patients and prolong the life of patients, but its adverse reactions are more and should be comprehensively and reasonably used clinically.