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目的分析盐酸米多君治疗体位性心动过速综合征(POTS)患儿的时间-疗效关系,以探讨盐酸米多君治疗POTS小儿的最佳用药周期。方法随访2005—2011年北京大学第一医院104例接受盐酸米多君治疗6个月的POTS患儿,依据治疗效果与用药时间的关系进行卡方检验并绘制时间-疗效曲线。结果依据盐酸米多君治疗时间,其累计有效率分别为1个月19.23%,2个月48.08%,3个月69.23%,4个月73.08%,5个月74.04%,6个月75.96%。卡方检验统计显示盐酸米多君治疗疗程为1个月及2个月时,其累计有效率与治疗疗程为3个月时的累计有效率相比较,差异有统计学意义(P<0.05),而治疗疗程为4、5和6个月时其累计有效率与治疗疗程为3个月时的累计有效率相比较,其差异均无统计学意义(P>0.05)。结论盐酸米多君治疗POTS小儿满3个月才能达到其最佳疗效,延长治疗疗程至6个月并不能显著提高治疗效果。
Objective To analyze the time-efficacy relationship of midodrine hydrochloride in patients with orthostatic tachycardia syndrome (POTS) to explore the best medication period of midodrine hydrochloride for POTS infants. Methods Follow-up: From January 2005 to January 2011, 104 POTS patients treated with midodrine hydrochloride for 6 months in Peking University First Hospital were analyzed by chi-square test and the time-response curve was drawn according to the relationship between the therapeutic effect and the time of treatment. Results According to the treatment time of midodrine hydrochloride, the cumulative effective rates were 19.23% for 1 month, 48.08% for 2 months, 69.23% for 3 months, 73.08% for 4 months, 74.04% for 5 months and 75.96% for 6 months, respectively . Chi-square test showed that when the treatment of midodrine hydrochloride for 1 month and 2 months, the cumulative effective rate was 3 months compared with the cumulative effective rate, the difference was statistically significant (P <0.05) , While the cumulative effective rate at 4, 5 and 6 months of treatment was not significantly different from the cumulative effective rate at 3 months after treatment (P> 0.05). Conclusion Midodrine hydrochloride POTS treatment of children over three months to achieve the best effect, prolonged treatment to 6 months and did not significantly improve the therapeutic effect.