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To investigate the relationship between follicular blood flow and the follicul ar fluid vascular endothelial growth factor (VEGF)-and nitric oxide (NO) concen trations and to determine which factor might be a better predictor of the outcom e of IVF-ET. Prospective study. Academic research laboratory. Forty-seven cycl es of IVF (tubal factor, 25 cycles; male factor, 22 cycles)-at the infertility clinic of Pusan National University Hospital from February 2002 to June 2002. Follicular blood flow was estimated on the day of hCG administration. Each follicular flui d sample was collected at oocyte retrieval, and follicular fluid VEGF and NO con centrations were assessed. Follicular blood flow and follicular fluid VEGF and N O concentrations according to the age of patients, the cause of infertility, and pregnancy rate. Of 47 cycles, 18 (38.3%) cycles resulted in a pregnancy. Folli cular blood flow was significantly higher in the pregnant group compared with th e nonpregnant group, but there was no statistically significant difference in ag e and infertility cause. Follicular fluid concentrations of VEGF and NO did not show statistically significant differences in age, infertility cause, or pregnan cy outcome. As the follicle size increases, the follicular blood flow and follic ular fluid VEGF concentrations increased significantly but the follicular fluid NO concentrations decreased. There was no correlation between VEGF and NO concen trations in the follicular fluid by linear regression analysis. Our study showed that follicular blood flow was positively associated with the outcome of pregna ncy. This is the first study to investigate the direct association of the follic ular blood flow with pregnancy outcome after IVF-ET. These results suggest that follicular blood flow might be a more effective prognostic marker of the pregna ncy outcome of IVF than follicular fluid VEGF or NO concentrations.
To investigate the relationship between follicular blood flow and the follicul ar fluid vascular endothelial growth factor (VEGF) -and nitric oxide (NO) concentrrations and determine which factor might be a better predictor of the outcom e of IVF-ET. Prospective study Forty-seven cycl es of IVF (tubal factor, 25 cycles; male factor, 22 cycles) -at the infertility clinic of Pusan National University Hospital from February 2002 to June 2002. Follicular blood flow was estimated on the day of follicular fluid and follicular fluid VEGF and NO concentrations according to the age of patients, the cause of infertility, and pregnancy Of 47 cycles, 18 (38.3%) cycles resulted in a pregnancy. Folli cular blood flow was significantly higher in the pregnant group compared with th e nonpregnant group, but there was no statistically significant difference in ag e and infertility cause. Follicular fluid concentrations of VEGF and NO did not show statistically significant differences in age, infertility cause, or pregnan cy outcome. As the follicle size increases, the follicular blood flow and follicular ular fluid VEGF levels increased significantly but the follicular fluid NO concentrations decreased. There was no correlation between VEGF and NO concen trations in the follicular fluid by linear regression analysis. Our study showed that follicular blood flow was positively associated with the outcome of pregna ncy. This is the first study to investigate the direct association of the follicular ular blood flow with pregnancy outcome after IVF-ET. These results suggest that follicular blood flow might be a more effective prognostic marker of the pregna ncy outcome of IVF than follicular fluid VEGF or NO concentrations .