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目前在生殖药物学领域里最引人注目的成就莫过于抗旱孕和催经止孕药物的开发与应用,主要包括甾体类孕酮受体拮抗剂、3β-羟甾脱氢酶抑制剂和前列腺素等。现将这方面的研究近况综述如下: 一、孕酮受体桔抗剂以RU 486(RU 38486,Mifepristone,mifegyne~(?))为代表的孕酮受体拮抗剂是甾体避孕药研究中的一项重大突破。RU 486对子宫内膜孕酮受体的亲和力比黄体酮强5倍,故能产生很强的抗孕酮活性。迄今该药
At present, the most remarkable achievements in the field of reproductive medicine are the development and application of drugs for fighting drought and promoting menstruation, which mainly include steroid progesterone receptor antagonists, 3β-hydroxysteroid dehydrogenase inhibitors and Prostaglandins and so on. The recent progress in this area are summarized as follows: First, the progesterone receptor orange antagonist RU 486 (RU 38486, Mifepristone, mifegyne ~ (?)) As a progesterone receptor antagonist is steroidal contraceptives in the study A major breakthrough. RU 486 progesterone receptor on the endometrium affinity progesterone stronger than 5 times, it can produce a strong anti-progesterone activity. So far the drug