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应用人类核仁形成区(NOR)选择性银染技术,对分别注射复方己酸孕酮注射剂和复方甲地孕酮微囊注射剂,以及正常对照妇女进行外周血淋巴细胞NOR的研究。结果注射组、自身对照组及正常对照组银染核仁形成区(Ag-NOR)的分布,在丹佛体制分组水平上呈随机分布。注射组与对照组的 Ag-NOR频率,以及自身对照组注射前后的Ag-NOR频率,均无显著差异,表明这两种药物对用药妇女外周血淋巴细胞有活性的rRNA基因数目没有影响。注射组和自身对照组注射后银染的近端着丝粒染色体联合(Ag-AA)频率,均比对照组和自身对照组注射前显著增高,表明这两种药物有增加用药妇女外周血淋巴细胞rRNA基因活性的作用。
The selective silver staining of human nucleolar organizer region (NOR) was used to study the NOR of peripheral blood lymphocytes in mice injected with compound caproic acid and progesterone injection and compound megestrol microcapsule injection respectively. Results The distributions of Ag-NOR in injection group, self-control group and normal control group were randomly distributed in the Denver institutional grouping level. There was no significant difference in the Ag-NOR frequency between the injected group and the control group and the Ag-NOR frequency before and after the injection in the self-control group, indicating that the two drugs have no effect on the number of rRNA genes that are active in the peripheral blood lymphocytes of the treated women. The frequency of Ag-AA near the silver staining in the injection group and the self-control group was significantly higher than that of the control group and the self-control group after injection, indicating that the two drugs have increased the peripheral blood lymphocytes The role of cellular rRNA gene activity.