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虎眼万年青皂苷OSW-1来源于百合科植物虎眼万年青,是一种具有良好抗肿瘤活性的皂苷成分.其类似物23-Oxa-OSW-1具有OSW-1一样潜在的活性,对恶性肿瘤细胞具有很强的抑制作用,IC50为0.052～0.4μmol·L-1.但OSW-1的生物靶标还没有报道.利用一维和二维1H NMR技术首次发现23-Oxa-OSW-1与DNA间有很强的相互作用.NMR数据分析表明23-Oxa-OSW-1中木糖部分可能参与了与DNA的结合.
The tiger-eye evergreen saponin OSW-1 is derived from the evergreen alkaloids of Liliaceae plant, and is a saponin component with good anti-tumor activity. Its analogue 23-Oxa-OSW-1 has the same potential activity as OSW-1, and it is also a malignant tumor. The cells have a strong inhibitory effect, with an IC50 of 0.052 to 0.4 μmol·L-1. However, biological targets of OSW-1 have not been reported yet. The first discovery of 23-Oxa-OSW-1 and DNA was made using 1D and 2D 1H NMR techniques. There is a strong interaction. Analysis of NMR data shows that the xylose moiety in 23-Oxa-OSW-1 may be involved in DNA binding.