作者对6例绒癌脑转移及13例非脑转移病例的血清和脑脊液HCG、β-HCG进行了连续测定,探讨了两者之间的关系。发现在脑转移的病例中,血清与脑脊液中的HCG和β-HCG之比值偏低。脑脊液中的HCG,一部分是血中的HCG通过血脑屏障而来,另一部分则是脑转移灶直接释放入脑脊液。Brightman等人认为:当脑转移灶周围的血脑屏障发生障碍,加之新生毛细血管的内皮细胞接合部异常时,脑脊液中蛋白浓度的变化亦受到影响。因此猜想在脑转移时血清和脑脊液的 The authors measured 6 cases of choriocarcinoma brain metastases and 13 cases of non-brain metastases serum and cerebrospinal fluid HCG, β-HCG were measured continuously to explore the relationship between the two. In cases of brain metastases, the ratio of HCG to β-HCG in serum and cerebrospinal fluid was found to be low. HCG in cerebrospinal fluid, part of the blood HCG through the blood-brain barrier from the other part of the brain metastases directly into the cerebrospinal fluid. Brightman and others argue that changes in protein concentration in cerebrospinal fluid are also affected when there is an obstacle to the blood-brain barrier around the brain metastasis, combined with an abnormal endothelial cell junction in the nascent capillaries. So guess the serum and cerebrospinal fluid during brain metastases