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目的:探讨戈舍瑞林治疗三苯氧胺(TAM)引起的绝经前激素受体阳性年轻乳腺癌患者卵巢囊肿的治疗效果。方法:36例服用三苯氧胺后出现卵巢囊肿(直径>5 cm)的激素受体阳性绝经前乳腺癌术后患者联用戈舍瑞林治疗为治疗组,42例服用三苯氧胺后出现卵巢囊肿(直径>5 cm)的激素受体阳性绝经前乳腺癌术后患者单作停药处理为观察组。结果:治疗组加用戈舍瑞林6个月后卵巢囊肿均消失,观察2年后无1例再出现卵巢囊肿;观察组停药后卵巢囊肿能缩小,观察2年后仅4例患者卵巢囊肿消失。两组比较,差异有统计学意义(χ~2=63.51,P=0.001)。结论:戈舍瑞林能有效治疗三苯氧胺引起的绝经前年轻乳腺癌患者卵巢囊肿。
Objective: To investigate the therapeutic effect of goserelin on ovarian cysts in patients with premenopausal hormone receptor-positive young breast cancer caused by tamoxifen (TAM). Methods: 36 patients with ovarian cysts (> 5 cm in diameter) who had ovarian cysts (> 5 cm in diameter) were treated with goserelin for the postoperative patients and 42 for ovariectomy (diameter> 5 cm) of hormone receptor-positive postmenopausal breast cancer patients treated with single withdrawal for the observation group. Results: Ovarian cysts disappeared after treatment with goserelin for 6 months in the treatment group. No ovarian cyst was found in 1 case after 2 years observation. Ovarian cysts could be reduced in the observation group after stopping the treatment. Only 4 patients were ovariectomized after 2 years Cysts disappear. The difference between the two groups was statistically significant (χ ~ 2 = 63.51, P = 0.001). CONCLUSIONS: Goserelin is effective in the treatment of ovarian cysts in patients with early breast cancer due to tamoxifen.