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收集了仅有１６岁以下青少年为子女的支气管哮喘核心家系的资料。２３０个家系资料的分析结果表明：１６岁以下的青少年中，男性患哮喘的危险性是女性的１．６２倍（Ｐ＜０．０１），饮用塘河水的人产生哮喘的危险性明显比饮用自来水的人高（ＯＲ＝１．６７，Ｐ＜０．０５）。父母的哮喘史是青少年最为突出的危险因素，使青少年患哮喘的危险性分别增加２．０６和２．７３倍，且均具有高度显著性意义。此家系分析也显示，母亲的哮喘史对子女产生哮喘的影响更大，约为父亲的两倍。青少年自身的气道高反应性和过敏体质也是青少年产生哮喘的危险因素之一，优势比分别为１．９２和２．０１（Ｐ＜０．０１）。本文揭示了遗传因素在哮喘发病过程中可能的重要作用。
Information was collected on the nuclear pedigrees of bronchial asthma in adolescents only under the age of 16 years. Analysis of 230 pedigree data showed that among men younger than 16 years, the risk of asthma in men was 1.62 times higher than that in women (P <0.01). People who drank pond water had a significantly higher risk of developing asthma than those who drank People with tap water were higher (OR = 1.67, P <0.05). Parents asthma history is the most prominent risk factors for adolescents, adolescents risk of asthma increased by 2.06 and 2.73 times, respectively, and are highly significant. The pedigree analysis also showed that the mother’s history of asthma had a greater impact on their children’s asthma, about twice as much as their dads. Adolescent airway hyperresponsiveness and allergic constitution are also risk factors for asthma in adolescents, with odds ratios of 1.92 and 2.01, respectively (P <0.01). This article reveals the possible role of genetic factors in the pathogenesis of asthma.