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基质金属蛋白酶(MMPs)是一组在结构上具有极大同源性、活性依赖Zn2+和Ca2+的内肽酶,对维持正常组织结构和功能的细胞外基质(extracellular matrix,ECM)具有特异性的水解特性[1]。目前已有研究证明,肺结核患者血清MMP9显著高于健康人群,可作为肺结核辅助性诊断指标,而MMP9表达水平的变化与抗结核治疗效果之间的关系,尚未见报道。本研究通过观察肺结核患者抗结核治疗过程中
Matrix metalloproteinases (MMPs) are a group of endopeptidases with great structural homology and activity dependent on Zn2 + and Ca2 +, which are specific to the extracellular matrix (ECM) that maintains normal tissue structure and function Hydrolysis characteristics [1]. At present, studies have shown that the serum MMP9 of patients with tuberculosis is significantly higher than that of healthy people, which can be used as an auxiliary diagnostic indicator of tuberculosis. However, the relationship between the change of MMP9 expression and the anti-TB treatment effect has not been reported yet. This study was designed to observe the anti-TB treatment in patients with tuberculosis