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目的探讨薄片液基细胞学检查(TCT)配合阴道镜宫颈活检在宫颈上皮瘤样病变(CIN)的筛查诊断及宫颈冷刀锥切治疗CIN的临床效果。方法 248例患者行液基薄层细胞检测(TCT)检查,发现意义不明的不典型鳞状细胞(ASCUS)患者108例,阴道镜图像异常的取活检,发现CIN 2~3级的患者(55例)行宫颈冷刀锥切。结果患者术后病理检查发现CIN 2~3级48例,7例病检结果为子宫颈乳头状糜烂,经过4~6个月随访,并行复查取活检,宫颈外观愈合良好,未发现异常。结论 TCT检测、阴道镜检查、病理学检测,经过三步检查,就可以发现宫颈上皮内瘤样病变CIN,而宫颈冷刀锥切是治疗CIN的最有效方法。CIN治疗后的随访也很重要。
Objective To investigate the screening diagnosis of cervical intraepithelial neoplasia (CIN) by thin-section liquid-based cytology (TCT) combined with colposcopy cervical biopsy and the clinical effect of cervical cold knife conization in the treatment of CIN. Methods A total of 248 patients underwent liquid-based thin-layer cytometry (TCT) examination and found that there were 108 cases with undetermined significance in atypical squamous cell carcinoma (ASCUS) and colposcopy abnormalities. The patients with CIN grade 2 to 3 (55 Case) line cervical cold knife conization. Results The postoperative pathological examination found 48 cases of CIN 2 ~ 3 grade, 7 cases of pathological examination of cervical papillary erosion, after 4 to 6 months follow-up, parallel examination and biopsy, cervical appearance was well healed, no abnormalities were found. Conclusions TCT, colposcopy and pathological examination can be used to detect cervical intraepithelial neoplasia (CIN) after three steps of examination, while cold knife conization is the most effective method to treat CIN. Follow-up after CIN treatment is also important.