为达到攻克肿瘤的目的,了解肿瘤的发生、发展的分子机理及其引起的细胞生长、分化等过程的异常至关重要。但是肿瘤的起源及其进展是许多极其复杂过程的共同结果。目前,分子机制研究得较深入的肿瘤当属慢性髓系白血病(chronic myeloid leukemia,CML)。本文拟从CML中c-ABL的激活、可能的信号传递途径以及造血调控的特点和临床表现的关系的角度,概述CML发生、发展的分子机理。 In order to achieve the purpose of conquering tumors, understanding the molecular mechanism of the occurrence and development of tumors and the abnormalities of cell growth, differentiation, and other processes that are caused are critical. But the origin and progression of the tumor are the common result of many extremely complex processes. At present, the most in-depth study of molecular mechanisms is chronic myeloid leukemia (CML). This article outlines the molecular mechanisms underlying the occurrence and development of CML from the perspective of the activation of c-ABL in CML, possible signaling pathways, and the relationship between the characteristics and clinical manifestations of hematopoietic regulation.