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红细胞的变形性对维持正常微循环的血流是必要的。最近的研究表明,败血症时虽然心输出量增加,全身处于高血流状态,但肝、肾、肌肉的血流减少。这很可能与红细胞变形能力改变有关,后者对细胞损伤可能起重要作用。为研究人及鼠在败血症时红细胞变形能力是否受累,对一组术后败血症患者、术后无败血症患者、正常对照及另一组接受盲肠手术、接受假手术、接受大肠杆菌内毒素引起败血症的鼠,取血测定其红细胞变形指数。变形指数[D1=H(60s)/t]。H为红细胞压积。t为1.0ml红细胞在室温、-20cmH_2O条件下,通过4.7μm聚碳酸酯滤器的时间。
Deformability of erythrocytes is essential for maintaining normal microcirculation of blood flow. Recent studies have shown that while sepsis increased cardiac output, the whole body in a high blood flow state, but the liver, kidney and muscle blood flow decreased. This is likely to be associated with changes in erythrocyte deformability, which may play an important role in cell damage. To study whether human and mouse erythrocyte deformability is involved in sepsis, a group of postoperative sepsis patients, postoperative patients without sepsis, normal controls and another group received cecal surgery, undergoing sham surgery, receiving endotoxin-induced sepsis Rats, blood determination of erythrocyte deformability index. Deformation index [D1 = H (60s) / t]. H is hematocrit. t is the time of passage of 1.0 ml of erythrocytes through a 4.7 μm polycarbonate filter at -20 cmH 2 O at room temperature.