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用薄层聚丙烯酰胺凝胶等电聚焦方法对62例全身性红斑狼疮(SLE)、61例寻常型银屑病(PV)及17例胰岛素依赖性糖尿病(IDDM)病人补体第二途径成份B因子SS型的亚型分布及基因频率进行了检测。结果表明,SLB病人BfSS亚基因频率分别为,S_A0.516,S_B0.484;PV为:S_A0.492,S_B0.508,IDDM为:S_A0.676,S_B0.324。与正常人(S_A0.414,S_B0.586)比较,三种疾病的S_A亚基因频率均有不同程度的增高,并伴有S_B亚基因频率的降低。统计结果表明,IDDM与正常人的差异显著(P<0.01),SLE次之(P<0.05),PV不著(P>0.1)。此外,这三种疾病病人BfS_A-S_A亚型的表型频率(分别为30.6%、31.1%和41.1%)都显著高于正常19.3%),统计学表明差异均显著(P<0.05)。
Sixty-two patients with systemic lupus erythematosus (SLE), 61 patients with psoriasis vulgaris (PV), and 17 patients with insulin-dependent diabetes mellitus (IDDM) were treated with the isoelectric focusing method of thin layer polyacrylamide gel Subtypes of SS genotypes and gene frequencies were examined. The results showed that the frequencies of BfSS subfamilies in patients with SLB were S_A0.516 and S_B0.484, PVs were S_A0.492 and S_B0.508, IDDM was S_A0.676 and S_B0.324 respectively. Compared with normal subjects (S_A0.414, S_B0.586), the frequencies of S_A subunit in all three diseases were increased to some extent, accompanied by the decrease of the frequency of S_B subunit. The statistical results show that there is significant difference between IDDM and normal subjects (P <0.01), SLE (P <0.05) and PV (P> 0.1). In addition, the phenotypic frequencies of BfS_A-S_A subtypes (30.6%, 31.1% and 41.1%, respectively) in these three diseases were significantly higher than those in normal subjects (19.3%). Statistical differences were significant (P <0.05).