NF-κB是一类重要的转录调节因子,调控免疫反应和炎症反应中多种蛋白的基因转录。NF-κB的活化及其对基因转录的调节与炎症性肠病的发病机制和治疗关系密切。 NF-κB is a class of important transcriptional regulators that regulate gene transcription of multiple proteins in the immune and inflammatory responses. The activation of NF-κB and its regulation of gene transcription are closely related to the pathogenesis and treatment of inflammatory bowel disease.