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目的观察应用不同剂量辛伐他汀治疗脑梗死的临床效果,并分析其药理作用,总结应用体会。方法选取医院收治的脑梗死患者102例,随机分为观察组和对照组,每组51例。对照组给予常规剂量的辛伐他汀进行治疗,观察组则在对照组基础上给予双倍剂量的辛伐他汀治疗,观察2组治疗方法的临床效果及不良反应发生情况。结果观察组治疗总有效率为92.16%,高于对照组的81.39%(P<0.05);观察组不良反应发生率为3.92%,对照组不良反应发生率为5.88%,2组比较差异无统计学意义(P>0.05)。结论在对脑梗死患者进行治疗时,可在常规治疗的基础上给予双倍剂量(40 mg/d)辛伐他汀进行治疗,可有效提高临床治疗效果,且不会升高不良反应发生率,具有临床推广应用价值。
Objective To observe the clinical effects of different doses of simvastatin in the treatment of cerebral infarction and to analyze its pharmacological effects and to summarize its application experience. Methods Totally 102 patients with cerebral infarction admitted to hospital were randomly divided into observation group and control group, with 51 cases in each group. The control group was given conventional dose of simvastatin for treatment. The observation group was given double dose of simvastatin on the basis of the control group. The clinical effects and adverse reactions of the two groups were observed. Results The total effective rate of the observation group was 92.16%, which was higher than that of the control group (81.39%) (P <0.05). The incidence of adverse reactions in the observation group was 3.92% and the incidence of adverse reactions in the control group was 5.88% Significance (P> 0.05). Conclusion In the treatment of patients with cerebral infarction, double-dose (40 mg / d) simvastatin can be given on the basis of routine treatment, which can effectively improve the clinical effect without increasing the incidence of adverse reactions, Has clinical application value.