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目的:探讨急性心力衰竭患者血浆N末端B型利钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)、肌钙蛋白Ⅰ(cTnⅠ)和糖类抗原125(CA125)与心功能的相关性。方法:选择杭州市大江东医院2017年5月至2019年5月收治的急性心力衰竭患者97例为观察组，根据纽约心脏病协会(NYHA)心功能分级，Ⅱ级组29例，Ⅲ级组51例，Ⅳ级组17例；另选择该院2017年5月至2019年5月健康体检者50例为对照组。比较两组血浆NT-proBNP、hs-CRP、cTnⅠ和CA125水平变化及心功能指标[左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF)]变化；比较不同心功能分级组血浆NT-proBNP、hs-CRP、cTnⅠ和CA125水平变化及LVEDD和LVEF变化；分析NT-proBNP、hs-CRP、cTnⅠ和CA125与LVEDD和LVEF相关性。结果:观察组血浆NT-proBNP[(5 684.21±174.39)ng/L]、hs-CRP[(16.54±3.27)mg/L]、cTnⅠ[(0.43±0.13)μg/L]和CA125[(83.24±15.46)U/mL]均高于对照组(n t＝216.813、25.684、19.432、34.138，均n P<0.05)。观察组LVEDD[(63.21±4.87)mm]高于对照组[(48.97±2.41)mm]，而LVEF[(39.27±3.25)%]低于对照组[(62.87±4.36)%](n t＝19.461、37.008，均n P<0.05)。Ⅳ级组血浆NT-proBNP[(7 368.18±201.05)ng/L]、hs-CRP[(24.19±4.18)mg/L]、cTnⅠ[(0.63±0.14)μg/L]和CA125[(164.52±27.48)U/mL]均高于Ⅱ级组和Ⅲ级组(Ⅲ级组：n t＝31.109、6.557、5.321、13.017，Ⅱ级组：n t＝75.873、16.582、11.755、23.178，均n P<0.05)；Ⅲ级组血浆NT-proBNP[(5 751.42±180.34)ng/L]、hs-CRP[(15.98±4.56)mg/L]、cTnⅠ[(0.41±0.15)μg/L]和CA125[(87.97±18.45)U/mL]均高于Ⅱ级组[(3481.34±145.26)ng/L、(8.23±2.37)mg/L、(0.25±0.08)μg/L和(28.43±12.21)U/mL](n t＝57.893、8.507、5.320、15.530，均n P<0.05)。Ⅳ级组LVEDD[(67.95±5.15)mm]高于Ⅱ级组和Ⅲ级组(Ⅲ级组：n t＝3.553，Ⅱ级组：n t＝8.157，均n P<0.05)，而LVEF[(34.28±2.36)%]低于Ⅱ级组和Ⅲ级组(Ⅲ级组：n t＝6.673，Ⅱ级组：n t＝10.417，均n P<0.05)；Ⅲ级组LVEDD[(62.78±5.21)mm]高于Ⅱ级组[(57.87±3.25)mm](n t＝4.586，n P<0.05)，而LVEF[(39.98±3.24)%]低于Ⅱ级组[(45.98±4.25)%](n t＝7.097，n P<0.05)。LVEDD与NT-proBNP、hs-CRP、cTnⅠ和CA125呈线性正相关；LVEF与NT-proBNP、hs-CRP、cTnⅠ和CA125呈线性负相关。n 结论:急性心力衰竭患者血浆NT-proBNP、hs-CRP、cTnⅠ和CA125水平升高，且与心功能分级和心功能指标具有明显相关性。“,”Objective:To investigate the relationship between plasma N-terminal B-type natriuretic peptide precursor (NT-proBNP), hypersensitive C-reactive protein (hs-CRP), troponin Ⅰ (cTnⅠ) and carbohydrate antigen 125 (CA125) and cardiac function in patients with acute heart failure.Methods:From May 2017 to May 2019, 97 patients with acute heart failure admitted to Hangzhou Dajiangdong Hospital were selected as the observation group.According to the cardiac function classification of New York Heart Association (NYHA), 29 patients were classified as grade Ⅱ group, 51 patients as grade Ⅲ group and 17 patients as grade Ⅳ group.Fifty healthy people were selected as control group.The changes of plasma NT-proBNP, hs-CRP, cTnⅠ and CA125 levels, left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were compared between the two groups.The changes of plasma NT-proBNP, hs-CRP, cTnⅠ and CA125 levels, as well as the changes of LVED and LVEF in the different heart function grading group were compared.The correlation between plasma NT-proBNP, hs-CRP, cTnⅠ, CA125 and LVEDD, LVEF was analyzed.Results:The plasma NT-proBNP[(5 684.21±174.39)ng/L], hs-CRP[(16.54±3.27)mg/L], cTnⅠ[(0.43±0.13)g/L] and CA125[(83.24±15.46)U/mL] in the observation group were higher than those in the control group(n t=216.813, 25.684, 19.432, 34.138, all n P<0.05). The LVEDD in the observation group[(63.21±4.87)mm] was higher than that in the control group[(48.97±2.41)mm], and the LVEFin the observation group[(39.27±3.25)%] was lower than that in the control group[(62.87±4.36)%], the differences were statistically significant (n t=19.461, 37.008, all n P<0.05). The levels of NT-proBNP[(7 368.18±201.05)ng/L], hs-CRP[(24.19±4.18)mg/L], cTnⅠ[(0.63±0.14)μg/L] and CA125[(164.52±27.48)U/mL] in the grade Ⅳ group were higher than those in the grade Ⅱ group and grade Ⅲ group(grade Ⅲ group:n t=31.109, 6.557, 5.321, 13.017; grade Ⅱ group: n t=75.873, 16.582, 11.755, 23.178, all n P<0.05). The plasma NT-proBNP[(5 751.42±180.34)ng/L], hs-CRP[(15.98±4.56)mg/L], cTnⅠ[(0.41±0.15)g/L] and CA125[(87.97±18.45)U/mL] in the grade Ⅲ group were higher than those in the grade Ⅱ group[(3 481.34±145.26)ng/L, (8.23±2.37)mg/L, (0.25±0.08)μg/L and (28.43±12.21)U/mL](n t=57.893, 8.507, 5.320, 15.530, all n P<0.05). The LVEDD[(67.95±5.15)mm] in the grade Ⅳ group was higher than that in the grade Ⅱ group and grade Ⅲ group(grade Ⅲ group:n t=3.553, grade Ⅱ group: n t=8.157, n P<0.05), while the LVEF[(34.28±2.36)%] in the grade Ⅳ group was lower than that in the grade Ⅱ group and grade Ⅲ group(grade Ⅲ group:n t=6.673, grade Ⅱ group: n t=10.417, all n P<0.05). The LVEDD[(62.78±5.21)mm] in the grade Ⅲ group was higher than that in the grade Ⅱ group[(57.87±3.25)mm](n t=4.586, n P<0.05), while the LVEF in the grade Ⅲ group[(39.98±3.24)%] was lower than that in the grade Ⅱ group[(45.98±4.25)%](n t=7.097, n P<0.05). LVEDD was positively correlated with NT-proBNP, hs-CRP, cTnⅠ and CA125, while LVEF was negatively correlated with NT-proBNP, hs-CRP, cTnⅠ and CA125.n Conclusion:The levels of NT-proBNP, hs-CRP, cTnⅠ and CA125 in plasma of patients with acute heart failure are elevated, and they are significantly correlated with cardiac function grading and cardiac function indicators.