透明质酸 (hyaluronan ,HA)是一种主要的细胞外基质成分 ,炎症及肿瘤等病理情况下含量明显增多。HA一方面通过其粘弹性作用在细胞周围形成网状屏障 ,从而限制巨噬细胞的吞噬活动 ;而另一方面当HA与巨噬细胞表面HA结合受体CD4 4和RHAMM结合时 ,可引起巨噬细胞内细胞骨架的重组并激活细胞内一系列信号转导过程 ,从而促进巨噬细胞对凋亡细胞等的吞噬。 Hyaluronic acid (hyaluronan, HA) is a major component of the extracellular matrix, inflammation and tumor pathological conditions such as significantly increased content. HA, on the one hand, forms a reticular barrier around cells by its viscoelasticity and thus inhibits the phagocytosis of macrophages. On the other hand, when HA binds to the macrophage surface HA-binding receptors CD4 4 and RHAMM, Reorganization of cytoskeleton in the macrophages and activation of a series of signal transduction processes within the cell, thereby promoting macrophage phagocytosis of apoptotic cells and the like.