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目的 探索预测某一地区风湿热 (RF)流行状况简便的方法。方法 对广东 2 16名城乡学龄儿童血清抗DNA酶B和抗链球菌溶血素“O”(ASO)水平进行为期 1年的动态观察 ;另外在5个不同地区中 ,各抽取 10 0名学龄儿童在同一季节进行抗DNA酶B水平横贯面的调查 ,结果与同期风湿热 /风湿性心脏病 (RF/RHD)发患病率对照研究。结果 抗DNA酶B水平呈秋、冬、春季高 ,夏季低的季节性变化 ,与RF发病率的季节性分布规律一致 (r =0 913,P <0 0 5 )。抗DNA酶B水平高的地区 ,其RF/RHD发患病率高 ,反之则低 (r=0 95 2 ,P <0 0 5 )。结论 测定某一地区学龄儿童血清抗DNA酶B水平 ,可作为该地区RF/RHD流行水平的初步估测和进一步研究的参考。
Objective To explore ways to predict the prevalence of rheumatic fever (RF) in a particular area. Methods The dynamic changes of serum anti-DNase B and anti-streptolysin “O” (ASO) levels in 2 16 school-age children in urban and rural areas of Guangdong Province were observed for one year. In addition, 10 school-age children In the same season, anti-DNase B translocation was investigated and the results were compared with the prevalence of rheumatic fever / rheumatic heart disease (RF / RHD) in the same season. Results The seasonal changes of anti-DNase B levels in autumn, winter, spring and summer were consistent with the seasonal distribution of RF incidence (r = 0 913, P 0 05). Areas with high levels of anti-DNase B had a high prevalence of RF / RHD and vice versa (r = 0 952, P <0 05). Conclusion The determination of serum anti-DNase B level in school-age children in a certain area can be used as a preliminary estimate and further reference for the prevalence of RF / RHD in this area.