p16基因位于人类染色体9p21,其编码蛋白特异性抑制CDK4和CDK6的活性,参与正常细胞周期调控。在肿瘤中,p16基因存在广泛而频繁的缺失和突变,被认为是新的抑癌基因。就p16基因的发现、结构和生物学特性,基因改变与肿瘤的关系,以及在p16基因研究的意义和前景做简要概括。 The p16 gene is located on the human chromosome 9p21 and encodes a protein that specifically inhibits the activity of CDK4 and CDK6 and is involved in the regulation of normal cell cycle. In tumors, p16 gene has extensive and frequent deletions and mutations, is considered a new tumor suppressor gene. The p16 gene discovery, structural and biological characteristics, gene changes and tumor relationship, as well as in the p16 gene research significance and prospects briefly.